DExH-box helicase 29 (DHX29) is a 155 kDa protein that in humans is encoded by the DHX29 gene.
Function
This gene encodes a member of the DEAH (Asp-Glu-Ala-His) subfamily of proteins, part of the DEAD (Asp-Glu-Ala-Asp) box family of RNA helicases. The encoded protein functions in translation initiation, and is specifically required for ribosomal scanning across stable mRNA secondary structures during initiation codon selection. This protein may also play a role in sensing virally derived cytosolic nucleic acids. Knockdown of this gene results in reduced protein translation and impaired proliferation of cancer cells.
Interactions
DHX29 has been shown to interact with the eukaryotic small ribosomal subunit (40S) and eIF3.
See also
- Eukaryotic translation
- DExD/H box proteins
- Ded1/DDX3
References
Further reading
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
